Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
The method includes detailed molecular simulations of the catalytic and allosteric binding pockets, along with ensemble virtual screening that considers their conformational flexibility. In the design of modulators, structural changes induced by reaction intermediates are taken into account to enhance activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P49591
UPID:
SYSC_HUMAN
Alternative names:
Seryl-tRNA synthetase; Seryl-tRNA(Ser/Sec) synthetase
Alternative UPACC:
P49591; B2R6Y9; Q5T5C8; Q9NSE3
Background:
Serine--tRNA ligase, cytoplasmic, also known as Seryl-tRNA synthetase, plays a crucial role in protein synthesis by catalyzing the attachment of serine to tRNA(Ser). This enzyme is essential for the accurate translation of the genetic code into functional proteins. It also has a unique ability to aminoacylate tRNA(Sec) with serine, a critical step in selenocysteine incorporation, and regulates angiogenesis by modulating VEGFA expression.
Therapeutic significance:
The protein is implicated in a neurodevelopmental disorder characterized by microcephaly, ataxia, and seizures. Understanding the role of Serine--tRNA ligase, cytoplasmic could open doors to potential therapeutic strategies for this and related genetic disorders.