Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P49619
UPID:
DGKG_HUMAN
Alternative names:
Diglyceride kinase gamma
Alternative UPACC:
P49619; B2RAH4; Q2M1H4; Q5FWG1
Background:
Diacylglycerol kinase gamma, also known as Diglyceride kinase gamma, plays a pivotal role in cellular signaling by converting diacylglycerol (DAG) into phosphatidic acid (PA). This conversion is crucial for regulating the balance between DAG and PA, two bioactive lipids with opposing functions in various biological processes. The enzyme exhibits broad specificity for the acyl compositions of DAG and is predominantly expressed in the cerebellum. It is instrumental in controlling DAG levels, thereby indirectly influencing protein kinase C gamma activity, dendritic development of Purkinje cells, cerebellar long-term depression, and motor coordination.
Therapeutic significance:
Understanding the role of Diacylglycerol kinase gamma could open doors to potential therapeutic strategies.