Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P49641
UPID:
MA2A2_HUMAN
Alternative names:
Alpha-mannosidase IIx; Mannosidase alpha class 2A member 2; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
Alternative UPACC:
P49641; A6NH12; A8K1E8; Q13754
Background:
Alpha-mannosidase 2x, known alternatively as Alpha-mannosidase IIx, Mannosidase alpha class 2A member 2, and Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, plays a pivotal role in the biosynthesis of complex N-glycans. It is instrumental in the conversion of high mannose to complex N-glycans, marking the final hydrolytic step in the N-glycan maturation pathway.
Therapeutic significance:
Understanding the role of Alpha-mannosidase 2x could open doors to potential therapeutic strategies.