Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P49643
UPID:
PRI2_HUMAN
Alternative names:
DNA primase 58 kDa subunit
Alternative UPACC:
P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413
Background:
The DNA primase large subunit, also known as the 58 kDa subunit, is a crucial component of the DNA polymerase alpha complex. This complex is essential for the initiation of DNA synthesis, playing a pivotal role during the S phase of the cell cycle. It is involved in the formation of RNA primers necessary for DNA replication, working closely with other subunits within the complex to ensure accurate DNA synthesis across both leading and lagging strands.
Therapeutic significance:
Understanding the role of DNA primase large subunit could open doors to potential therapeutic strategies.