Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P49763
UPID:
PLGF_HUMAN
Alternative names:
-
Alternative UPACC:
P49763; Q07101; Q9BV78; Q9Y6S8
Background:
Placenta growth factor (PlGF) is a pivotal molecule in angiogenesis and endothelial cell dynamics, promoting their proliferation and migration. It specifically interacts with the FLT1/VEGFR-1 receptor, and in its isoform PlGF-2, it also binds to NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Furthermore, PlGF is known to facilitate tumor growth by enhancing cell proliferation.
Therapeutic significance:
Understanding the role of Placenta growth factor could open doors to potential therapeutic strategies. Its involvement in angiogenesis and cell proliferation makes it a promising target for developing treatments aimed at regulating blood vessel growth in diseases and inhibiting tumor progression.