Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P49802
UPID:
RGS7_HUMAN
Alternative names:
-
Alternative UPACC:
P49802; Q5T3H4; Q8TD66; Q8TD67; Q8WW09; Q9UNU7; Q9Y6B9
Background:
Regulator of G-protein signaling 7 (RGS7) is a critical component of the RGS7-GNB5 complex, pivotal in regulating G protein-coupled receptor signaling pathways. It inhibits signal transduction by enhancing the GTPase activity of G protein alpha subunits, leading to their inactive GDP-bound form. RGS7 is implicated in synaptic vesicle exocytosis and modulates potassium channels activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling.
Therapeutic significance:
Understanding the role of Regulator of G-protein signaling 7 could open doors to potential therapeutic strategies.