Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P50542
UPID:
PEX5_HUMAN
Alternative names:
PTS1-BP; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1
Alternative UPACC:
P50542; A8K891; B4DZ45; B7ZAD5; D3DUT8; Q15115; Q15266; Q96FN7
Background:
The Peroxisomal targeting signal 1 receptor, known as Peroxin-5, plays a crucial role in the peroxisomal import of proteins. It specifically recognizes and transports proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal into the peroxisome matrix. This process is essential for peroxisome biogenesis and function, highlighting the receptor's pivotal role in cellular metabolism and detoxification.
Therapeutic significance:
Peroxin-5's dysfunction is linked to severe disorders such as Peroxisome biogenesis disorder 2A and 2B, and Rhizomelic chondrodysplasia punctata 5, characterized by neurologic, liver, and skeletal abnormalities. Understanding the role of Peroxin-5 could open doors to potential therapeutic strategies for these life-threatening conditions.