Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P51003
UPID:
PAPOA_HUMAN
Alternative names:
Polynucleotide adenylyltransferase alpha
Alternative UPACC:
P51003; Q86SX4; Q86TV0; Q8IYF5; Q9BVU2
Background:
Poly(A) polymerase alpha, also known as Polynucleotide adenylyltransferase alpha, plays a crucial role in mRNA processing by creating the 3'-poly(A) tail. This enzyme's activity is essential for the stability and translation efficiency of mRNA molecules. It functions through interaction with cleavage and polyadenylation specificity factor (CPSF) at its C-terminus, highlighting its specificity in polyadenylation sites.
Therapeutic significance:
Understanding the role of Poly(A) polymerase alpha could open doors to potential therapeutic strategies. Its pivotal function in mRNA processing makes it an intriguing target for modulating gene expression in various diseases.