Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P51553
UPID:
IDH3G_HUMAN
Alternative names:
Isocitric dehydrogenase subunit gamma; NAD(+)-specific ICDH subunit gamma
Alternative UPACC:
P51553; E9PDD5; Q9BUU5
Background:
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, known as Isocitric dehydrogenase subunit gamma or NAD(+)-specific ICDH subunit gamma, plays a pivotal role in cellular metabolism. It is a regulatory subunit essential for the allosteric regulation of the enzyme that catalyzes the decarboxylation of isocitrate into alpha-ketoglutarate, a critical step in the citric acid cycle.
Therapeutic significance:
Understanding the role of Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial could open doors to potential therapeutic strategies.