Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P51800
UPID:
CLCKA_HUMAN
Alternative names:
ClC-K1
Alternative UPACC:
P51800; B4DPD3; E7EPH6; Q5T5P8; Q5T5Q4; Q7Z6D1; Q86VT1
Background:
The Chloride channel protein ClC-Ka, also known as ClC-K1, plays a pivotal role in the regulation of cell volume, membrane potential stabilization, signal transduction, and transepithelial transport. Its significance is underscored in urinary concentrating mechanisms, highlighting its essential function in maintaining electrolyte balance.
Therapeutic significance:
ClC-Ka's involvement in Bartter syndrome 4B, a condition characterized by impaired salt reabsorption, hypokalemic metabolic alkalosis, and sensorineural deafness, underscores its therapeutic potential. Targeting ClC-Ka could lead to innovative treatments for this syndrome, emphasizing the importance of understanding its biological mechanisms.