Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P51828
UPID:
ADCY7_HUMAN
Alternative names:
ATP pyrophosphate-lyase 7; Adenylate cyclase type VII; Adenylyl cyclase 7
Alternative UPACC:
P51828; A0AVA6
Background:
Adenylate cyclase type 7, also known as ATP pyrophosphate-lyase 7, plays a pivotal role in catalyzing the formation of cAMP in response to G protein-coupled receptors activation. It is integral in signaling cascades triggered by thrombin, sphingosine 1-phosphate, dopamine, and C5 alpha chain, enhancing cAMP synthesis through the synergistic action of stimulatory G proteins. This enzyme is crucial in modulating innate immune responses and controlling inflammation during bacterial infections, as well as in the optimal functioning of B and T cells during adaptive immune responses.
Therapeutic significance:
Understanding the role of Adenylate cyclase type 7 could open doors to potential therapeutic strategies, especially in the modulation of immune responses and inflammation control.