Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P52306
UPID:
GDS1_HUMAN
Alternative names:
Exchange factor smgGDS; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein
Alternative UPACC:
P52306; E9PH06; G5E9P9; Q499L7; Q4KMV2; Q4QQI8; Q9BUW9; Q9BUX6; Q9NYM2; Q9NZA8
Background:
Rap1 GTPase-GDP dissociation stimulator 1, known as Exchange factor smgGDS, plays a pivotal role in cellular processes by acting as a guanine nucleotide exchange factor (GEF) for the Rho family of G proteins. It facilitates the exchange of GDP for GTP, enhancing the activity of proteins like RAP1A/B, RHOA, RHOB, RHOC, RAC1, and KRAS. Beyond its GEF activity, it serves as a chaperone for small GTPases, aiding in their processing and trafficking, and influences mitochondrial dynamics and calcium release from the endoplasmic reticulum.
Therapeutic significance:
Understanding the role of Rap1 GTPase-GDP dissociation stimulator 1 could open doors to potential therapeutic strategies.