Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P53618
UPID:
COPB_HUMAN
Alternative names:
Beta-coat protein
Alternative UPACC:
P53618; D3DQX0; Q6GTT7; Q9NTK2; Q9UNW7
Background:
The Coatomer subunit beta, also known as Beta-coat protein, is pivotal in cellular transport mechanisms. It binds to dilysine motifs and associates with Golgi non-clathrin-coated vesicles, facilitating protein transport from the ER through the Golgi to the trans Golgi network. This protein is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins and plays a crucial role in lipid homeostasis, Golgi structural integrity, and autophagy.
Therapeutic significance:
Linked to Baralle-Macken syndrome, a disorder marked by developmental delays, cataracts, and potential metabolic abnormalities, the Coatomer subunit beta's genetic variants highlight its clinical importance. Understanding the role of Coatomer subunit beta could open doors to potential therapeutic strategies for this syndrome.