Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P53621
UPID:
COPA_HUMAN
Alternative names:
Alpha-coat protein; HEP-COP
Alternative UPACC:
P53621; Q5T201; Q8IXZ9
Background:
The Coatomer subunit alpha, also known as Alpha-coat protein or HEP-COP, plays a crucial role in cellular transport mechanisms. It is involved in the transport of proteins from the ER to the Golgi and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Its function is pivotal for maintaining the Golgi structural integrity and influences the processing and recycling of LDL receptors.
Therapeutic significance:
Given its involvement in Autoimmune interstitial lung, joint, and kidney disease, understanding the role of Coatomer subunit alpha could lead to novel therapeutic strategies targeting the underlying mechanisms of this autoimmune disorder.