Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P53999
UPID:
TCP4_HUMAN
Alternative names:
Positive cofactor 4; SUB1 homolog; p14
Alternative UPACC:
P53999; Q96L29
Background:
Activated RNA polymerase II transcriptional coactivator p15, also known as Positive cofactor 4, SUB1 homolog, and p14, plays a pivotal role in gene expression. It acts as a general coactivator, enhancing the interactions between upstream activators and the transcriptional machinery. Its ability to bind single-stranded DNA and, in vitro, double-stranded DNA, underscores its versatility in gene regulation.
Therapeutic significance:
Understanding the role of Activated RNA polymerase II transcriptional coactivator p15 could open doors to potential therapeutic strategies.