Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P54253
UPID:
ATX1_HUMAN
Alternative names:
Spinocerebellar ataxia type 1 protein
Alternative UPACC:
P54253; Q17S02; Q9UJG2; Q9Y4J1
Background:
Ataxin-1, known as the Spinocerebellar ataxia type 1 protein, plays a pivotal role in chromatin-binding, acting as a corepressor in the Notch signaling pathway. It is involved in brain development, RNA metabolism, and represses Notch signaling by binding to the HEY promoter alongside NCOR2 and RBPJ. Its ability to bind RNA in vitro suggests a broader role in RNA metabolism.
Therapeutic significance:
Spinocerebellar ataxia 1, a disease linked to Ataxin-1, is characterized by progressive incoordination and cerebellum degeneration. The disease stems from a CAG repeat expansion in ATXN1, leading to earlier onset and severe manifestations with longer expansions. Understanding Ataxin-1's role could unveil new therapeutic strategies for this debilitating condition.