Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
We utilise our cutting-edge, exclusive workflow to develop focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P54317
UPID:
LIPR2_HUMAN
Alternative names:
Cytotoxic T lymphocyte lipase; Galactolipase; Triacylglycerol lipase
Alternative UPACC:
P54317; A0A075B781; A8K627; Q6IB55
Background:
Pancreatic lipase-related protein 2, also known as Cytotoxic T lymphocyte lipase, Galactolipase, and Triacylglycerol lipase, plays a pivotal role in lipid metabolism. It hydrolyzes triglycerides and galactosylglycerides, crucial for dietary fat digestion, especially in neonates. This protein is adept at breaking down fats of varying chain lengths and is essential for the absorption of long-chain polyunsaturated fatty acids from a plant-based diet. Its activity shifts from triglyceride hydrolysis to galactolipase and monoacylglycerol lipase as the liver matures.
Therapeutic significance:
Understanding the role of Pancreatic lipase-related protein 2 could open doors to potential therapeutic strategies.