Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P54368
UPID:
OAZ1_HUMAN
Alternative names:
-
Alternative UPACC:
P54368; O43382; Q14989; Q92595; Q9UPL9
Background:
Ornithine decarboxylase antizyme 1 plays a pivotal role in regulating polyamine biosynthesis and uptake, crucial for cellular growth and differentiation. It inhibits ornithine decarboxylase (ODC) activity, preventing the assembly of functional ODC homodimers, and facilitates their degradation. This protein also modulates the stability of AZIN2 and the cellular uptake of polyamines, showcasing its multifaceted regulatory functions in intracellular polyamine levels.
Therapeutic significance:
Understanding the role of Ornithine decarboxylase antizyme 1 could open doors to potential therapeutic strategies. Its regulatory function in polyamine biosynthesis and cellular uptake positions it as a key target for modulating cellular growth and differentiation, offering avenues for the development of novel treatments.