Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Key features that set our library apart include:
partner
Reaxense
upacc
P54578
UPID:
UBP14_HUMAN
Alternative names:
Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14
Alternative UPACC:
P54578; B7Z4N8; J3QRZ5; Q53XY5
Background:
Ubiquitin carboxyl-terminal hydrolase 14, also known as Deubiquitinating enzyme 14, plays a crucial role in proteasome-associated deubiquitination, ensuring ubiquitin regeneration. It functions both as a part of the proteasome and independently within the cell, facilitating the degradation of specific proteins like the chemokine receptor CXCR4, critical for cell chemotaxis. Additionally, it acts as a physiological inhibitor of ERAD under non-stressed conditions and is vital for synaptic development at neuromuscular junctions. Its role in stabilizing the viral DNA sensor CGAS highlights its importance in the innate immune defense against viruses.
Therapeutic significance:
Understanding the role of Ubiquitin carboxyl-terminal hydrolase 14 could open doors to potential therapeutic strategies.