Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.
Our library stands out due to several important features:
partner
Reaxense
upacc
P54619
UPID:
AAKG1_HUMAN
Alternative names:
-
Alternative UPACC:
P54619; B4DDT7; Q8N7V9
Background:
The 5'-AMP-activated protein kinase subunit gamma-1 is a pivotal component of AMPK, a crucial energy sensor that modulates cellular energy metabolism. This protein responds to low ATP levels by activating energy production and inhibiting energy consumption, affecting processes like protein, carbohydrate, and lipid biosynthesis, as well as cell growth. It also plays a role in cellular polarity by affecting the actin cytoskeleton.
Therapeutic significance:
Understanding the role of 5'-AMP-activated protein kinase subunit gamma-1 could open doors to potential therapeutic strategies.