Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P55160
UPID:
NCKPL_HUMAN
Alternative names:
Hematopoietic protein 1; Membrane-associated protein HEM-1
Alternative UPACC:
P55160; B4DUT5; Q52LW0
Background:
Nck-associated protein 1-like, also known as Hematopoietic protein 1 and Membrane-associated protein HEM-1, plays a pivotal role in the regulation of the actin cytoskeleton. It is crucial for lymphocyte development, activation, proliferation, and homeostasis, as well as for erythrocyte membrane stability. This protein is a component of the WAVE2 complex, facilitating F-actin polymerization and influencing T-cell and neutrophil migration.
Therapeutic significance:
The protein's involvement in Immunodeficiency 72 with autoinflammation and lymphoproliferation highlights its potential as a target for therapeutic intervention. Understanding the role of Nck-associated protein 1-like could open doors to potential therapeutic strategies for treating this complex immunologic disorder.