Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P55287
UPID:
CAD11_HUMAN
Alternative names:
OSF-4; Osteoblast cadherin
Alternative UPACC:
P55287; A8K5D6; A8MZC8; B7WP28; Q15065; Q15066; Q9UQ93; Q9UQ94
Background:
Cadherin-11, also known as OSF-4 and Osteoblast cadherin, is a calcium-dependent cell adhesion protein vital for proper focal adhesion assembly and cell migration regulation. Its role is pivotal in the sorting of heterogeneous cell types, facilitating cell-to-cell interaction through homophilic manners.
Therapeutic significance:
Cadherin-11's involvement in Elsahy-Waters syndrome and Teebi hypertelorism syndrome 2, both genetic disorders affecting craniofacial morphology and intellectual development, underscores its potential as a target for therapeutic intervention. Understanding the role of Cadherin-11 could open doors to potential therapeutic strategies.