Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P55344
UPID:
LMIP_HUMAN
Alternative names:
MP18; MP19; MP20
Alternative UPACC:
P55344; Q6B083; Q9BXD0; Q9HAR5
Background:
The Lens fiber membrane intrinsic protein, known by its alternative names MP18, MP19, and MP20, is integral to the structure of mammalian lens fiber cells. It contributes to cell junctional organization and acts as a receptor for calmodulin, playing a pivotal role in lens development and potentially in cataractogenesis.
Therapeutic significance:
Given its involvement in Cataract, multiple types 19, a condition leading to visual impairment or blindness, understanding the role of Lens fiber membrane intrinsic protein could open doors to potential therapeutic strategies.