Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P55735
UPID:
SEC13_HUMAN
Alternative names:
GATOR complex protein SEC13; SEC13-like protein 1; SEC13-related protein
Alternative UPACC:
P55735; A8MV37; B4DXJ1; Q5BJF0; Q9BRM6; Q9BUG7
Background:
Protein SEC13 homolog, known as GATOR complex protein SEC13, plays a crucial role in cellular processes. It is a component of the nuclear pore complex (NPC) and the COPII coat, essential for the biogenesis of COPII-coated vesicles and the secretion of specific proteins from the endoplasmic reticulum. Additionally, as part of the GATOR2 subcomplex, it activates mTORC1 signaling, a key pathway in cell growth and metabolism, regulated by amino acid availability.
Therapeutic significance:
Understanding the role of Protein SEC13 homolog could open doors to potential therapeutic strategies. Its involvement in critical cellular pathways like mTORC1 signaling highlights its potential as a target in diseases where these pathways are dysregulated.