Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P55771
UPID:
PAX9_HUMAN
Alternative names:
-
Alternative UPACC:
P55771; Q99582; Q9UQR4
Background:
Paired box protein Pax-9 plays a crucial role in the development of various organs, including thymus, parathyroid glands, and teeth. It functions as a transcription factor, essential for the normal formation of skeletal elements of the skull, larynx, and distal limbs.
Therapeutic significance:
The protein's mutation is linked to Tooth agenesis, selective, 3, a condition characterized by the congenital absence of one or more teeth. Understanding the role of Paired box protein Pax-9 could open doors to potential therapeutic strategies for dental anomalies.