Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P56199
UPID:
ITA1_HUMAN
Alternative names:
CD49 antigen-like family member A; Laminin and collagen receptor; VLA-1
Alternative UPACC:
P56199; B2RNU0
Background:
Integrin alpha-1, also known as CD49 antigen-like family member A, serves as a crucial receptor for laminin and collagen. It specifically recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen, playing a pivotal role in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
Therapeutic significance:
Understanding the role of Integrin alpha-1 could open doors to potential therapeutic strategies. Its interaction with laminin and collagen highlights its importance in cellular adhesion and signaling pathways, suggesting avenues for intervention in related pathological conditions.