Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P56597
UPID:
NDK5_HUMAN
Alternative names:
Inhibitor of p53-induced apoptosis-beta; Testis-specific nm23 homolog; nm23-H5
Alternative UPACC:
P56597; B2R5G7
Background:
Nucleoside diphosphate kinase homolog 5, also known as Inhibitor of p53-induced apoptosis-beta and Testis-specific nm23 homolog, plays a crucial role in the motility of sperm and cilia. It is part of axonemal radial spoke complexes and is involved in protecting cells from death by Bax, while also regulating the levels of several antioxidant enzymes.
Therapeutic significance:
Linked to Ciliary dyskinesia, primary, 48, without situs inversus, this protein's dysfunction leads to severe respiratory infections and chronic inflammation. Understanding its role could pave the way for innovative treatments for primary ciliary dyskinesia.