Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P56645
UPID:
PER3_HUMAN
Alternative names:
Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3
Alternative UPACC:
P56645; Q5H8X4; Q5H8X5; Q969K6; Q96S77; Q96S78; Q9C0J3; Q9NSP9; Q9UGU8
Background:
Period circadian protein homolog 3, also known as Cell growth-inhibiting gene 13 protein, plays a pivotal role in the circadian clock. This internal time-keeping system regulates physiological processes through 24-hour rhythms in gene expression, influencing metabolism, sleep, and other vital functions. The protein is part of a transcription/translation feedback loop crucial for maintaining circadian rhythms, with implications for cardiovascular health, cancer, metabolic syndromes, and aging.
Therapeutic significance:
Linked to Advanced sleep phase syndrome, familial, 3, Period circadian protein homolog 3's understanding could pave the way for innovative treatments targeting sleep disorders and circadian rhythm disruptions.