Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P56915
UPID:
GSC_HUMAN
Alternative names:
-
Alternative UPACC:
P56915; Q86YR1
Background:
Homeobox protein goosecoid plays a pivotal role in embryonic development, regulating chordin and defining neural crest cell fate. It is crucial for organogenesis, particularly in the development of the middle ear and skeletal system.
Therapeutic significance:
Understanding the role of Homeobox protein goosecoid could open doors to potential therapeutic strategies for Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities, a disorder linked to gene variants.