Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P57076
UPID:
CF298_HUMAN
Alternative names:
Protein kurly homolog
Alternative UPACC:
P57076; Q53FH0
Background:
Cilia- and flagella-associated protein 298, also known as Protein kurly homolog, is pivotal in motile cilium function. It is implicated in outer dynein arm assembly, crucial for cilium motility initiation and correct apical cell surface positioning. This protein's involvement in the planar cell polarity pathway and its potential to suppress canonical Wnt signaling underscores its multifaceted biological role.
Therapeutic significance:
Linked to Primary Ciliary Dyskinesia 26, characterized by motile cilia abnormalities leading to severe respiratory infections and potential situs inversus, understanding the role of Cilia- and flagella-associated protein 298 could open doors to potential therapeutic strategies.