Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P57678
UPID:
GEMI4_HUMAN
Alternative names:
Component of gems 4; p97
Alternative UPACC:
P57678; Q9NZS7; Q9UG32; Q9Y4Q2
Background:
Gem-associated protein 4, also known as Component of gems 4 or p97, plays a crucial role in the assembly of small nuclear ribonucleoproteins (snRNPs), essential for pre-mRNA splicing. This process is fundamental for the accurate expression of genetic information.
Therapeutic significance:
The protein is linked to a severe neurodevelopmental disorder characterized by microcephaly, cataracts, and renal abnormalities. Understanding its role could lead to novel therapeutic strategies for this condition.