Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P57679
UPID:
EVC_HUMAN
Alternative names:
DWF-1; Ellis-van Creveld syndrome protein
Alternative UPACC:
P57679
Background:
The EvC complex member EVC, also known as DWF-1 or Ellis-van Creveld syndrome protein, plays a crucial role in the regulation of ciliary Hedgehog signaling, pivotal for endochondral growth and skeletal development. This protein's involvement in the EvC complex underscores its significance in cellular signaling pathways that dictate skeletal formation and growth.
Therapeutic significance:
Mutations in the EVC protein are directly linked to Ellis-van Creveld syndrome and Acrofacial dysostosis, Weyers type, highlighting its critical role in skeletal anomalies and cardiac defects. Understanding the EVC protein's function offers a promising avenue for developing targeted therapies for these genetic disorders, potentially mitigating their impact on affected individuals.