Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our top-notch dedicated system is used to design specialised libraries for enzymes.
Fig. 1. The sreening workflow of Receptor.AI
It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P57727
UPID:
TMPS3_HUMAN
Alternative names:
Serine protease TADG-12; Tumor-associated differentially-expressed gene 12 protein
Alternative UPACC:
P57727; D3DSJ6; Q5USC7; Q6ZMC3
Background:
Transmembrane protease serine 3, also known as serine protease TADG-12 or tumor-associated differentially-expressed gene 12 protein, plays a crucial role in hearing. It acts as a serine protease with a significant function in cochlear and saccular hair cell survival, essential for auditory processes.
Therapeutic significance:
Linked to autosomal recessive deafness, 8, understanding the role of Transmembrane protease serine 3 could open doors to potential therapeutic strategies for sensorineural hearing loss, a condition resulting from damage to the inner ear or neural pathways.