Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P58335
UPID:
ANTR2_HUMAN
Alternative names:
Capillary morphogenesis gene 2 protein
Alternative UPACC:
P58335; Q4W5H6; Q59E98; Q5JPE9; Q86UI1; Q8N4J8; Q8NB13; Q96NC7
Background:
Anthrax toxin receptor 2, also known as Capillary morphogenesis gene 2 protein, plays a crucial role in cellular interactions with laminin and the extracellular matrix. It serves as a receptor for the protective antigen of B.anthracis, facilitating its internalization and the subsequent escape of anthrax toxin components to the cytoplasm.
Therapeutic significance:
Hyaline fibromatosis syndrome, a disease marked by abnormal growth of hyalinized fibrous tissue and severe mobility limitations, is linked to mutations affecting this protein. Understanding the role of Anthrax toxin receptor 2 could open doors to potential therapeutic strategies for this debilitating condition.