Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P58546
UPID:
MTPN_HUMAN
Alternative names:
Protein V-1
Alternative UPACC:
P58546
Background:
Myotrophin, also known as Protein V-1, plays a pivotal role in cellular processes, including the dimerization of NF-kappa-B subunits and the regulation of NF-kappa-B transcription factor activity. It is instrumental in actin filament growth regulation and inhibits the F-actin-capping protein complex. Furthermore, Myotrophin promotes cardiomyocyte growth and cardiac muscle hypertrophy, highlighting its significance in cardiac biology.
Therapeutic significance:
Understanding the role of Myotrophin could open doors to potential therapeutic strategies, especially in the context of cardiac health and diseases. Its involvement in cardiomyocyte growth and cardiac muscle hypertrophy presents a promising avenue for developing treatments aimed at heart conditions.