Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P59047
UPID:
NALP5_HUMAN
Alternative names:
Mater protein homolog; Maternal Antigen that Embryos Require
Alternative UPACC:
P59047; A8MTY4; Q86W29
Background:
The NACHT, LRR, and PYD domains-containing protein 5, known as Mater protein homolog or Maternal Antigen that Embryos Require, is pivotal in early embryonic development. It regulates actin dynamics, essential for zygote division, and is involved in the formation of F-actin cytoplasmic lattices in oocytes. This protein ensures symmetric division by regulating mitotic spindle formation and positioning. It also plays a role in the localization of cortical granules and actin clearance in oocytes, and in post-fertilization Ca(2+) release and endoplasmic reticulum storage.
Therapeutic significance:
Understanding the role of NACHT, LRR, and PYD domains-containing protein 5 could open doors to potential therapeutic strategies.