Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P60002
UPID:
ELOF1_HUMAN
Alternative names:
-
Alternative UPACC:
P60002; Q8R1J7; Q96II4
Background:
Transcription elongation factor 1 homolog plays a pivotal role in the maintenance of chromatin structure during transcription elongation. Its function ensures the proper unfolding and refolding of chromatin, allowing for efficient gene expression in actively transcribed regions. This protein's involvement in chromatin dynamics highlights its importance in the regulation of gene expression, a fundamental process in cellular function and identity.
Therapeutic significance:
Understanding the role of Transcription elongation factor 1 homolog could open doors to potential therapeutic strategies. Its critical function in gene expression regulation suggests that modulating its activity could influence the outcome of various genetic and epigenetic diseases. Although direct associations with specific diseases are yet to be established, the protein's fundamental role in transcription elongation makes it a promising target for drug discovery efforts aimed at correcting gene expression anomalies.