Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
We employ our advanced, specialised process to create targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P60059
UPID:
SC61G_HUMAN
Alternative names:
-
Alternative UPACC:
P60059; B2R4J0; P38384; Q6IB25
Background:
Protein transport protein Sec61 subunit gamma is a crucial component of the SEC61 channel-forming translocon complex, facilitating the transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). It plays a pivotal role in cotranslational translocation of nascent polypeptides and ER membrane insertion of transmembrane proteins, working in tandem with the translocating protein TRAM1.
Therapeutic significance:
Understanding the role of Protein transport protein Sec61 subunit gamma could open doors to potential therapeutic strategies.