Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P60323
UPID:
NANO3_HUMAN
Alternative names:
-
Alternative UPACC:
P60323; Q495E5
Background:
Nanos homolog 3, identified by the accession number P60323, is pivotal in maintaining the undifferentiated state of germ cells. It regulates the spermatogonia cell cycle, ensuring a prolonged G1 phase, and represses the translation of specific mRNAs to affect cell proliferation. Its role is crucial in suppressing apoptotic pathways, thereby maintaining the germ cell lineage and protecting migrating primordial germ cells (PGCs) in early-stage embryos from apoptosis.
Therapeutic significance:
Understanding the role of Nanos homolog 3 could open doors to potential therapeutic strategies, particularly in the realm of reproductive health and the preservation of germ cell lineage.