AI-ACCELERATED DRUG DISCOVERY

Focused On-demand Library for Zona pellucida sperm-binding protein 1

Available from Reaxense
Predicted by Alphafold

Focused On-demand Libraries - Reaxense Collaboration

Explore the Potential with AI-Driven Innovation

The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.

We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.

Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.

Our high-tech, dedicated method is applied to construct targeted libraries.

 Fig. 1. The sreening workflow of Receptor.AI

Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.

Our library is unique due to several crucial aspects:

  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.
  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.
  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.
  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.

partner

Reaxense

upacc

P60852

UPID:

ZP1_HUMAN

Alternative names:

Zona pellucida glycoprotein 1

Alternative UPACC:

P60852

Background:

Zona pellucida sperm-binding protein 1, also known as Zona pellucida glycoprotein 1, plays a crucial role in fertilization. It is a key component of the zona pellucida, the extracellular matrix that surrounds oocytes. This protein mediates critical processes such as sperm binding, induction of the acrosome reaction, and prevention of post-fertilization polyspermy, ensuring the structural integrity of the zona pellucida.

Therapeutic significance:

The protein's involvement in Oocyte/zygote/embryo maturation arrest 1, an autosomal recessive infertility disorder, underscores its therapeutic significance. Understanding the role of Zona pellucida sperm-binding protein 1 could open doors to potential therapeutic strategies for treating infertility disorders related to defective oocyte maturation.

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