Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P60852
UPID:
ZP1_HUMAN
Alternative names:
Zona pellucida glycoprotein 1
Alternative UPACC:
P60852
Background:
Zona pellucida sperm-binding protein 1, also known as Zona pellucida glycoprotein 1, plays a crucial role in fertilization. It is a key component of the zona pellucida, the extracellular matrix that surrounds oocytes. This protein mediates critical processes such as sperm binding, induction of the acrosome reaction, and prevention of post-fertilization polyspermy, ensuring the structural integrity of the zona pellucida.
Therapeutic significance:
The protein's involvement in Oocyte/zygote/embryo maturation arrest 1, an autosomal recessive infertility disorder, underscores its therapeutic significance. Understanding the role of Zona pellucida sperm-binding protein 1 could open doors to potential therapeutic strategies for treating infertility disorders related to defective oocyte maturation.