Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P60900
UPID:
PSA6_HUMAN
Alternative names:
27 kDa prosomal protein; Macropain iota chain; Multicatalytic endopeptidase complex iota chain; Proteasome iota chain
Alternative UPACC:
P60900; B2R7J9; B4DQR4; B4DXJ9; P34062; Q6IB60
Background:
Proteasome subunit alpha type-6, also known as 27 kDa prosomal protein, plays a pivotal role in the proteolytic degradation of intracellular proteins. Integral to the 20S core proteasome complex, it is crucial for maintaining cellular protein homeostasis by eliminating misfolded or damaged proteins and regulating protein levels required for cellular functions.
Therapeutic significance:
Understanding the role of Proteasome subunit alpha type-6 could open doors to potential therapeutic strategies.