Explore the Potential with AI-Driven Innovation
Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
We use our state-of-the-art dedicated workflow for designing focused libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P61024
UPID:
CKS1_HUMAN
Alternative names:
-
Alternative UPACC:
P61024; P33551
Background:
Cyclin-dependent kinases regulatory subunit 1 plays a pivotal role in cell cycle regulation by binding to the catalytic subunit of cyclin-dependent kinases. This interaction is crucial for the activation and function of these kinases, which are key drivers of cell cycle progression.
Therapeutic significance:
Understanding the role of Cyclin-dependent kinases regulatory subunit 1 could open doors to potential therapeutic strategies. Its central role in cell cycle regulation makes it a potential target for interventions in diseases characterized by dysregulated cell proliferation.