Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library includes a list of the most effective modulators, each annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Furthermore, each compound is shown with its optimal docking poses, affinity scores, and activity scores, offering a detailed summary.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Our library distinguishes itself through several key aspects:
partner
Reaxense
upacc
P61106
UPID:
RAB14_HUMAN
Alternative names:
-
Alternative UPACC:
P61106; B3KR31; P35287; Q5JVD4; Q6Q7K5; Q969L0; Q9UI11
Background:
Ras-related protein Rab-14 plays a pivotal role in membrane trafficking between the Golgi complex and endosomes during early embryonic development. It is crucial for the transport of FGFR-containing vesicles, influencing the development of the basement membrane, epiblast, and primitive endoderm lineages. Rab-14, in collaboration with DENND6A, modulates the endocytic transport of ADAM10 and N-cadherin/CDH2 shedding, impacting cell-cell adhesion.
Therapeutic significance:
Understanding the role of Ras-related protein Rab-14 could open doors to potential therapeutic strategies. Its involvement in key developmental processes and cell adhesion mechanisms presents it as a target for research in developmental disorders and diseases related to cell adhesion.