Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P61160
UPID:
ARP2_HUMAN
Alternative names:
Actin-like protein 2
Alternative UPACC:
P61160; B2RCP5; D6W5F4; E9PF41; O15142; Q96C82
Background:
Actin-related protein 2, also known as Actin-like protein 2, plays a pivotal role in cellular dynamics as part of the Arp2/3 complex. This complex is crucial for actin polymerization, facilitating branched actin network formation in the cytoplasm, essential for cell motility. It interacts with the pointed end of daughter actin filaments and is vital in podocyte lamellipodia formation, nuclear actin polymerization for gene transcription, and DNA repair.
Therapeutic significance:
Understanding the role of Actin-related protein 2 could open doors to potential therapeutic strategies.