Explore the Potential with AI-Driven Innovation
The specialised, focused library is developed on demand with the most recent virtual screening and parameter assessment technology, guided by the Receptor.AI drug discovery platform. This approach exceeds the capabilities of traditional methods and offers compounds with higher activity, selectivity, and safety.
From a virtual chemical space containing more than 60 billion molecules, we precisely choose certain compounds. Our collaborator, Reaxense, aids in their synthesis and provision.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology leverages molecular simulations to examine a vast array of proteins, capturing their dynamics in both isolated forms and in complexes with other proteins. Through ensemble virtual screening, we thoroughly account for the protein's conformational mobility, identifying critical binding sites within functional regions and distant allosteric locations. This detailed exploration ensures that we comprehensively assess every possible mechanism of action, with the objective of identifying novel therapeutic targets and lead compounds that span a wide spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P61927
UPID:
RL37_HUMAN
Alternative names:
60S ribosomal protein L37; G1.16
Alternative UPACC:
P61927; B2R4H2; P02403; Q6IBB4; Q99883
Background:
The Large ribosomal subunit protein eL37, also known as 60S ribosomal protein L37 and G1.16, plays a crucial role in the ribosome, the cell's protein synthesis machinery. According to research findings (PubMed:23636399, PubMed:32669547), it is a component of the large ribosomal subunit, essential for the ribosome's function in translating mRNA into polypeptide chains.
Therapeutic significance:
Understanding the role of Large ribosomal subunit protein eL37 could open doors to potential therapeutic strategies.