Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by our associate Reaxense.
Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Our library stands out due to several important features:
partner
Reaxense
upacc
P62191
UPID:
PRS4_HUMAN
Alternative names:
26S proteasome AAA-ATPase subunit RPT2; Proteasome 26S subunit ATPase 1
Alternative UPACC:
P62191; B4DR63; P49014; Q03527; Q6IAW0; Q6NW36; Q96AZ3
Background:
The 26S proteasome regulatory subunit 4, also known as PSMC1, plays a crucial role in cellular homeostasis. It is a component of the 26S proteasome, a complex essential for the ATP-dependent degradation of ubiquitinated proteins. This process is vital for removing misfolded or damaged proteins and those no longer needed, thereby participating in cell cycle progression, apoptosis, and DNA damage repair.
Therapeutic significance:
The association of PSMC1 with the neurodevelopmental disorder characterized by poor growth, spastic tetraplegia, and hearing loss highlights its potential as a therapeutic target. Understanding the role of PSMC1 could open doors to potential therapeutic strategies for this and related disorders.