Explore the Potential with AI-Driven Innovation
The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
Our methodology employs molecular simulations to explore a wide array of proteins, capturing their dynamic states both individually and within complexes. Through ensemble virtual screening, we address conformational mobility, uncovering binding sites within functional regions and remote allosteric locations. This thorough exploration ensures no potential mechanism of action is overlooked, aiming to discover novel therapeutic targets and lead compounds across an extensive spectrum of biological functions.
Key features that set our library apart include:
partner
Reaxense
upacc
P62241
UPID:
RS8_HUMAN
Alternative names:
40S ribosomal protein S8
Alternative UPACC:
P62241; P09058; Q6IRL7
Background:
The Small ribosomal subunit protein eS8, encoded by the gene with accession number P62241, plays a pivotal role in protein synthesis. As a component of the small ribosomal subunit, it is integral to the ribosome's function in translating mRNA into polypeptide chains. This process involves the assembly of the SSU processome in the nucleolus, where ribosome biogenesis factors, RNA chaperones, and ribosomal proteins collaborate to facilitate RNA folding, modifications, rearrangements, and cleavage. The targeted degradation of pre-ribosomal RNA by the RNA exosome is also a critical step in this process.
Therapeutic significance:
Understanding the role of Small ribosomal subunit protein eS8 could open doors to potential therapeutic strategies.