Explore the Potential with AI-Driven Innovation
This extensive focused library is tailor-made using the latest virtual screening and parameter assessment technology, operated by the Receptor.AI drug discovery platform. This technique is more effective than traditional methods, offering compounds with improved activity, selectivity, and safety.
The compounds are cherry-picked from the vast virtual chemical space of over 60B molecules. The synthesis and delivery of compounds is facilitated by our partner Reaxense.
The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Our library is unique due to several crucial aspects:
partner
Reaxense
upacc
P62508
UPID:
ERR3_HUMAN
Alternative names:
ERR gamma-2; Estrogen receptor-related protein 3; Nuclear receptor subfamily 3 group B member 3
Alternative UPACC:
P62508; A8K4I0; A8K6I2; B3KY84; E9PGB7; F8W8J3; O75454; O96021; Q68DA0; Q6P274; Q6PK28; Q6TS38; Q9R1F3; Q9UNJ4
Background:
The Estrogen-related receptor gamma, known alternatively as ERR gamma-2, Estrogen receptor-related protein 3, or Nuclear receptor subfamily 3 group B member 3, is a pivotal orphan receptor. It functions as a transcription activator even without a bound ligand, specifically binding to an estrogen response element to activate reporter genes. This protein plays a crucial role in inducing the expression of PERM1 in skeletal muscle, highlighting its significance in muscle physiology.
Therapeutic significance:
Understanding the role of Estrogen-related receptor gamma could open doors to potential therapeutic strategies, particularly in enhancing muscle function and addressing metabolic disorders.