Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by our partner Reaxense.
The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.
Our high-tech, dedicated method is applied to construct targeted libraries.
Fig. 1. The sreening workflow of Receptor.AI
By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P62699
UPID:
YPEL5_HUMAN
Alternative names:
-
Alternative UPACC:
P62699; D6W568; Q65Z97; Q8R174; Q9D6M1; Q9UMX7; Q9Y3C9
Background:
Protein yippee-like 5 plays a crucial role in cellular processes as part of the CTLH E3 ubiquitin-protein ligase complex. It is instrumental in the ubiquitination and subsequent proteasomal degradation of HBP1, a transcription factor vital for cell proliferation. This protein's function underscores its importance in maintaining cellular homeostasis and growth.
Therapeutic significance:
Understanding the role of Protein yippee-like 5 could open doors to potential therapeutic strategies. Its involvement in cell proliferation and degradation pathways highlights its potential as a target for developing treatments aimed at regulating cell growth, offering new avenues for therapeutic intervention.