Explore the Potential with AI-Driven Innovation
This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.
We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Our partner Reaxense helps in synthesizing and delivering these compounds.
In the library, a selection of top modulators is provided, each marked with 38 ADME-Tox and 32 parameters related to physicochemical properties and drug-likeness. Also, every compound comes with its best docking poses, affinity scores, and activity scores, providing a comprehensive overview.
Our top-notch dedicated system is used to design specialised libraries.
Fig. 1. The sreening workflow of Receptor.AI
Utilising molecular simulations, our approach thoroughly examines a wide array of proteins, tracking their conformational changes individually and within complexes. Ensemble virtual screening enables us to address conformational flexibility, revealing essential binding sites at functional regions and allosteric locations. Our rigorous analysis guarantees that no potential mechanism of action is overlooked, aiming to uncover new therapeutic targets and lead compounds across diverse biological functions.
Several key aspects differentiate our library:
partner
Reaxense
upacc
P62875
UPID:
RPAB5_HUMAN
Alternative names:
DNA-directed RNA polymerase III subunit L; RNA polymerase II 7.6 kDa subunit; RPB10 homolog
Alternative UPACC:
P62875; P52436; Q6FHX3
Background:
DNA-directed RNA polymerases I, II, and III subunit RPABC5 plays a pivotal role in the transcription of DNA into RNA, utilizing ribonucleoside triphosphates. It is integral to the synthesis of ribosomal RNA precursors, mRNA precursors, functional non-coding RNAs, and small RNAs such as 5S rRNA and tRNAs. This protein is a common component of RNA polymerases I, II, and III, with Pol II being central to the basal RNA polymerase II transcription machinery.
Therapeutic significance:
Understanding the role of DNA-directed RNA polymerases I, II, and III subunit RPABC5 could open doors to potential therapeutic strategies.